Summary: Neurocomputing 5860 (2004) 359364
Synaptic equalization by anti-STDP
Clifton C. Rumsey , L.F. Abbott
Volen Center for Complex Systems and Department of Biology, Brandeis University, 415 South St.
MS013 Waltham, MA 02454-9110, USA
Experimental evidence has shown that in some neuron types, such as hippocampal CA1 neu-
rons, distally generated excitatory postsynaptic potentials (EPSPs) are scaled up in amplitude
compared to more proximally generated EPSPs such that EPSP magnitudes at the soma are ap-
proximately equal regardless of the dendritic location of origin. Using an equivalent cable model
neuron, we show that a particular form of spike-timing dependent plasticity (STDP) called
anti-STDP is capable of achieving this synaptic equalization. Anti-STDP equalizes synapses
through the equalization of synaptic e cacies. We show this result for both a passive dendritic
cable and for a cable containing a dendritic spike-initiation zone.
c 2004 Elsevier B.V. All rights reserved.
Keywords: Synaptic e cacy; Spike-timing dependent plasticity; Dendritic attenuation
Due to the attenuation e ect of dendrites, synapse location, in addition to intrinsic
synaptic strength, is important in the consideration of synaptic e cacy. We de˙ne