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Behavioral/Systems/Cognitive Functional Significance of Striatal Responses during
 

Summary: Behavioral/Systems/Cognitive
Functional Significance of Striatal Responses during
Episodic Decisions: Recovery or Goal Attainment?
Sanghoon Han,1 Scott A. Huettel,1,2 Ana Raposo,4 R. Alison Adcock,1,3 and Ian G. Dobbins5
1Department of Psychology, Yonsei University, Seoul 120-749, Korea, 2Department of Psychology and Neuroscience, Duke University, Durham, North
Carolina 27708-0086, 3Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina 27710, 4Department of Psychology,
University of Lisbon, 1649-013 Lisbon, Portugal, and 5Department of Psychology, Washington University in St. Louis, St. Louis, Missouri 63130-4899
Memory retrieval is typically a goal-directed behavior, and as such, potentially influenced by reinforcement and motivation processes.
Althoughstriatalactivationisoftenevidentduringmemoryretrieval,itsfunctionalsignificanceremainsunclearbecausetypicalmemory
paradigms do not control the motivational significance of memory decisions. We used event-related functional magnetic resonance
imaging (fMRI) to investigate striatal activation during recognition with and without performance-linked monetary incentives. During
initial performance in the absence of incentives, dorsal striatal activation for "Old" memory conclusions nonetheless exceeded that for
"New" conclusions regardless of the accuracy of these conclusions. In contrast, subsequent scans paired incentives with either "Old" or
"New" conclusions and demonstrated greater activation for whichever judgment was potentially rewarded, both with and without
performance feedback. The data demonstrate that striatal activation during recognition judgments does not signal monetary reward
receipt,cognitivefeedback,orsuccessfulepisodicretrieval.Instead,itisheavilydependentuponsatisfactionofthesubjectivegoalsofthe
observer.
Introduction
Outside of the laboratory, memory retrieval attempts are usually
performed in service of specific goals (Johnson et al., 1993; Sha-

  

Source: Adcock, R. Alison - Center for Cognitive Neuroscience & Department of Psychological and Brain Sciences, Duke University
Dobbins, Ian G. - Department of Psychology, Washington University in St. Louis

 

Collections: Biology and Medicine