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The Dipsogenic Effect of the ReninAngiotensin System in Elasmobranch Fish
 

Summary: The Dipsogenic Effect of the Renin­Angiotensin System
in Elasmobranch Fish
W. Gary Anderson,*,1
Yoshio Takei, and Neil Hazon*,

*School of Biology, Division of Environmental and Evolutionary Biology, Gatty Marine Laboratory, University of
St. Andrews, St. Andrews, Fife KY16 8LB, Scotland; and Ocean Research Institute, University of Tokyo,
Tokyo 164-8639, Japan
Accepted August 10, 2001
This study investigated the control of drinking in elasmo-
branch fish through manipulation of the homologous re-
nin­angiotensin system (RAS). The smooth muscle relax-
ant papaverine was found to increase basal drinking
levels in the European lesser-spotted dogfish, Scyliorhi-
nus canicula, almost 20-fold. However, this response was
significantly reduced with the coadministration of the
angiotensin-converting enzyme inhibitor captopril which
had no effect when administered alone. Captopril was
also found to block a 7-fold increase in drinking rate
following administration of homologous angiotensin I in

  

Source: Anderson, W. Gary - Department of Biological Sciences, University of Manitoba

 

Collections: Biology and Medicine