Summary: commentaries
TheJournalofClinicalInvestigation http://www.jci.org Volume117 Number8 August2007 2079
secretioninresponsetoavarietyofstimuli
(1).Thereducedinsulinsecretioninturn
explains the increased hepatic glucose
productionobserved.Therearestillmany
unansweredquestions:Istheconcentration
ofTCF7L2proteinincreasedinthecellin
additiontoTCF7L2RNA?Howisexpres-
sionincreasedbyintronicvariants?How
doesincreasedTCF7L2 expressionreduce
insulinsecretion?Thisisthefirstinaseries
ofstepstowardunderstandingtheassoci-
atedpathophysiology.Intheend,whatis
desiredfromscientificbreakthroughsis
improvedpreventionoftype2diabetesand
improvedtreatmentofthosewhodevelop
thedisease.Wearestillalongwayfrom
this,butthereisnowanewcellpathway
tobefurtherinvestigatedtoseeifitcanbe

Source: Akabas, Myles - Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University

Collections: Biology and Medicine