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Molecular Separation of Two Behavioral Phenotypes by a Mutation Affecting the Promoters of a Ca-Activated K Channel
 

Summary: Molecular Separation of Two Behavioral Phenotypes by a Mutation
Affecting the Promoters of a Ca-Activated K Channel
Nigel S. Atkinson, Robert Brenner, Whei-meih Chang, Jennette Wilbur, James L. Larimer, and Joyce Yu
Section of Neurobiology, School of Biological Sciences and the Institute for Cellular and Molecular Biology, The University
of Texas at Austin, Austin, Texas 78712-1064
The Drosophila slowpoke gene encodes a BK-type calcium-
activated potassium channel. Null mutations in slowpoke per-
turb the signaling properties of neurons and muscles and cause
behavioral defects. The animals fly very poorly compared with
wild-type strains and, after exposure to a bright but cool light or
a heat pulse, exhibit a "sticky-feet" phenotype. Expression of
slowpoke arises from five transcriptional promoters that ex-
press the gene in neural, muscle, and epithelial tissues. A
chromosomal deletion (ash218
) has been identified that re-
moves the neuronal promoters but not the muscle­tracheal cell
promoter. This deletion complements the flight defect of slow-
poke null mutants but not the sticky-feet phenotype. Electro-
physiological assays confirm that the ash218
chromosome re-

  

Source: Atkinson, Nigel - Section of Neurobiology, Division of Biological Sciences, University of Texas at Austin

 

Collections: Biology and Medicine