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Proc. Natl. Acad. Sci. USA Vol. 96, pp. 88298834, August 1999
 

Summary: Proc. Natl. Acad. Sci. USA
Vol. 96, pp. 8829­8834, August 1999
Applied Physical Sciences, Physiology
Complexity of terminal airspace geometry assessed by lung
computed tomography in normal subjects and patients
with chronic obstructive pulmonary disease
MICHIAKI MISHIMA, TOYOHIRO HIRAI, HARUMI ITOH§, YASUTAKA NAKANO, HIROAKI SAKAI, SHIGEO MURO,
KOICHI NISHIMURA, YOSHITAKA OKU, KAZUO CHIN, MOTOHARU OHI, TAKASHI NAKAMURA,
JASON H. T. BATES¶, ADRIANO M. ALENCAR , AND BE`LA SUKI ,
Departments of Physical Therapeutics, Pulmonary Medicine, and §Radiology, Kyoto University Hospital, Kyoto 606-8507, Japan; ¶Meakins-Christie
Laboratories, McGill University, Montreal, Canada H2X 2P2; and Department of Biomedical Engineering, Boston University, Boston, MA 02215
Communicated by Ewald R. Weibel, University of Bern, Herrenschwanden, Switzerland, June 3, 1999 (received for review September 1, 1998)
ABSTRACT Increases in the low attenuation areas (LAA)
of chest x-ray computed tomography images in patients with
chronic obstructive pulmonary disease (COPD) have been
reported to reflect the development of pathological emphy-
sema. We examined the statistical properties of LAA clusters
in COPD patients and in healthy subjects. In COPD patients,
the percentage of the lung field occupied by LAAs (LAA%)
ranged from 2.6 to 67.6. In contrast, LAA% was always <30%

  

Source: Alencar, Adriano Mesquita - Departamento de Física Geral, Universidade de São Paulo

 

Collections: Physics