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Toward an Artificial Golgi: Redesigning the Biological Activities of Heparan Sulfate on a Digital Microfluidic Chip
 

Summary: Toward an Artificial Golgi: Redesigning the Biological
Activities of Heparan Sulfate on a Digital Microfluidic Chip
Jeffrey G. Martin,,
Megha Gupta,
Yongmei Xu,|
Srinivas Akella,|
Jian Liu,|
Jonathan S. Dordick,,
and Robert J. Linhardt*,,,
Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy,
New York 12180, Department of Biology, Rensselaer Polytechnic Institute, Troy, New York
12180, Department of Computer Science, Rensselaer Polytechnic Institute, Troy, New York
12180, DiVision of Medicinal Chemistry and Natural Products, UNC Eshelman School of
Pharmacy, UniVersity of North Carolina, Chapel Hill, North Carolina 27599, and Department of
Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180
Received April 16, 2009; E-mail: linhar@rpi.edu
Abstract: Using digital microfluidics, recombinant enzyme technology, and magnetic nanoparticles, we
have created a functional prototype of an artificial Golgi organelle. Analogous to the natural Golgi, which
is responsible for the enzymatic modification of glycosaminoglycans immobilized on proteins, this artificial
Golgi enzymatically modifies glycosaminoglycans, specifically heparan sulfate (HS) chains immobilized

  

Source: Akella, Srinivas - Department of Computer Science, University of North Carolina, Charlotte

 

Collections: Engineering; Computer Technologies and Information Sciences