Home

About

Advanced Search

Browse by Discipline

Scientific Societies

E-print Alerts

Add E-prints

E-print Network
FAQHELPSITE MAPCONTACT US


  Advanced Search  

 
used. Such HF animals show elevated expression of MMP-2 and MMP-9 at 23 weeks without LV dilatation. However, LV
 

Summary: used. Such HF animals show elevated expression of MMP-2
and MMP-9 at 23 weeks without LV dilatation. However, LV
dilatation, LV systolic dysfunction, and pulmonary edema
occur at 26 weeks with further enhancement of the
expression and activity of MMPs. Administration of the
ACE inhibitor (enalarpil, 5 mg/kg/d) from 9 weeks prevents
such geometrical and functional deterioration. Thus, MMPs
appear to promote LV remodeling, and ACE blockade
inhibits MMP activation by reducing Ang II formation,
thereby preventing LV remodeling and dysfunction. These
recent in vitro and animal studies have provided promising
findings on the reduction of hypertension and LVH through
blockade of MMPs and the EGF-R. The extent to which
inhibition of these molecules is clinically applicable to the
prevention and treatment of hypertension and LVH in
human patients remains to be determined.
References
1 Armiento, J.D. (2002) Matrix metalloproteinase disruption of the
extracellular matrix and cardiac dysfunction. Trends Cardiovasc.
Med. 12, 97101

  

Source: Andres, Andrew - School of Life Sciences, University of Nevada at Las Vegas

 

Collections: Biology and Medicine