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Summary: 798 volume 16 number 8 august 2009 nature structural & molecular biology
Shan Zha, Cristian Boboila, Frederick W. Alt
are at the Howard Hughes Medical Institute,
The Children's Hospital, The CBR institute of
Biomedical Research, Harvard Medical School,
Boston, Massachusetts, USA.
e-mail: alt@enders.tch.harvard.edu
Mre11: roles in DNA repair beyond
homologous recombination
Shan Zha, Cristian Boboila & Frederick W Alt
The Mre11 protein has well-documented functions in the repair of DNA double-strand breaks via homologous
recombination. Now, several new studies reveal that Mre11 also has a role in mammalian DNA double-strand
break repair by nonhomologous end joining.
Eukaryotic cells have two well-characterized
DNA double-strand break (DSB) repair
pathways. Homologous recombination
accurately repairs postreplicative DSBs using
an intact template from a sister chromatid. In
contrast,nonhomologous end joining (NHEJ)
ligates DSBs without homology or with short
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