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Molecular Cell, Vol. 6, 329338, August, 2000, Copyright 2000 by Cell Press A Yeast Intronic Splicing Enhancer and Nam8p
 

Summary: Molecular Cell, Vol. 6, 329338, August, 2000, Copyright 2000 by Cell Press
A Yeast Intronic Splicing Enhancer and Nam8p
Are Required for Mer1p-Activated Splicing
which bind pre-mRNA and activate nearby splice sites
(Valcarcel and Green, 1996; Tacke and Manley, 1999).
Similarly, the hnRNPs A and B appear to bind pre-mRNA
Marc Spingola and Manuel Ares, Jr.*
Center for the Molecular Biology of RNA
Sinsheimer Laboratories
and repress nearby splice sites (Mayeda and Krainer,University of California, Santa Cruz
1992; Mayeda et al., 1993), while others like hnRNP HSanta Cruz, California 95064
and F might activate (or derepress) nearby splice sites
(Min et al., 1995; Chou et al., 1999). SR proteins and
the hnRNP A/B family have been hypothesized to act
Summary antagonistically to each other because changes in the
relative amount or activity of these two classes of factors
Three introns whose splicing is activated during meio- influence splice site selection in vivo and in vitro (May-
sis in S. cerevisiae contain a Mer1p-dependent splic- eda and Krainer, 1992; Mayeda et al., 1993; Caceres et
ing enhancer. The enhancer can impose Mer1p-acti- al., 1994; Hanamura et al., 1998). Some proteins of this
class, like polypyrimidine tract binding protein, havevated splicing upon the constitutively spliced actin

  

Source: Ares Jr., Manny - Department of Molecular, Cell, and Developmental Biology, University of California at Santa Cruz

 

Collections: Biology and Medicine