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Special issue on neuropeptides in stress and addiction: Stress and addiction are strongly related conditions that
 

Summary: Special issue on neuropeptides in stress and addiction:
Overview
Stress and addiction are strongly related conditions that
feedback onto each other at several levels. For example,
exposure to stressors can cause relapse to abuse of diverse
substances with addictive properties. Conversely, withdrawal
from drugs of abuse, or even the state of craving in the
absence of overt withdrawal, can serve as stressors that
produce many of the same physiological effects as observed
in the acute stress response. Moreover, stresses associated
with drug withdrawal act as negative reinforcers that
maintain or even augment addictive behaviors. Just as stress
contributes to addiction, substance abuse can alter the
neurobiological substrates that underlie the stress response,
affecting stress sensitivity or ability to cope with stressors.
Finally, the high co-morbidity of substance abuse and stress-
related psychiatric disorders, such as post-traumatic stress
disorder and depression, underscore the close relationship
between stress and addiction and the likelihood of shared
mechanisms.

  

Source: Aston-Jones, Gary - Department of Neurosciences, Medical University of South Carolina

 

Collections: Biology and Medicine