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Differential chromatin marking of introns and expressed exons by H3K36me3

Summary: Differential chromatin marking of introns and expressed
exons by H3K36me3
Paulina Kolasinska-Zwierz1, Thomas Down1, Isabel Latorre1, Tao Liu2, X Shirley Liu2,3 & Julie Ahringer1
Variation in patterns of methylations of histone tails reflects
and modulates chromatin structure and function1. To provide
a framework for the analysis of chromatin function in
Caenorhabditis elegans, we generated a genome-wide map of
histone H3 tail methylations. We find that C. elegans genes
show distributions of histone modifications that are similar to
those of other organisms, with H3K4me3 near transcription
start sites, H3K36me3 in the body of genes and H3K9me3
enriched on silent genes. We also observe a novel pattern:
exons are preferentially marked with H3K36me3 relative to
introns. H3K36me3 exon marking is dependent on transcription
and is found at lower levels in alternatively spliced exons,
supporting a splicing-related marking mechanism. We further
show that the difference in H3K36me3 marking between exons
and introns is evolutionarily conserved in human and mouse.
We propose that H3K36me3 exon marking in chromatin
provides a dynamic link between transcription and splicing.


Source: Ahringe, Julie - Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
Liu, Xiaole Shirley - Dana-Farber Cancer Institute & Department of Biostatistics, Harvard University


Collections: Biology and Medicine; Biotechnology; Computer Technologies and Information Sciences