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Elsevier Editorial System(tm) for Medical Engineering & Physics Manuscript Draft

Summary: Elsevier Editorial System(tm) for Medical Engineering & Physics
Manuscript Draft
Manuscript Number: MEP-D-04-00056R2
Title: Reduction of Compartment Compliance Increases Venous Flow Pulsatility and Lowers Apparent
Vascular Compliance: Implications for Cerebral Blood Flow Hemodynamics
Article Type: Paper
Section/Category: Regular Issue Paper
Keywords: Intracranial pressure; Windkessel model; Apparent compliance
Corresponding Author: Dr. Xiao Hu, PhD
Corresponding Author's Institution: University of California, Los Angeles
First Author: Xiao Hu, Ph.D.
Order of Authors: Xiao Hu, Ph.D.; Abeer A Alwan, Ph.D.; Eduardo H Rubinstein, M.D., Ph.D; Marvin
Bergsneider, M.D.
Manuscript Region of Origin:
Abstract: The global compliance of a fixed-volume, incompressible compartment may play a significant role
in determining the inherent vascular compliance. For the intracranial compartment, we propose that the free-
displacement of the cerebral spinal fluid (CSF) directly relates to cerebral vascular compliance. To test this
hypothesis, an in vivo surrogate intracranial compartment was made by enclosing a rabbit's kidney within a
rigid, fluid-filled container. Opening/closing a port atop the box modulated the free flow of box fluid (open-box
state). We observed that the pulsatility of the renal venous outflow increased in response to hampering the


Source: Alwan, Abeer - Electrical Engineering Department, University of California at Los Angeles


Collections: Computer Technologies and Information Sciences