Summary: Brain Activity for Osteoarthritis Pain : an fMRI Study
M.V. Centeno1, P.Y.Geha1, A.V. Apkarian1, J.A. Katz2, M.N. Baliki1, D.R. Chialvo1
1.Department of Physiology, 2. Department of Anesthesiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611
We have shown that the brain of chronic
pain patients is functionally and
morphologically affected by the chronic
condition (Apkarian et al. 2004). In this
study, we investigate brain activity of knee
osteoarthritis (OA) patients in response to a
painful pressure stimulus.
Contrasting brain activity underlying
nociception in these patients with that of
normal subjects aid in unraveling the
dynamics of the major brain areas encoding
chronic pain and provide a history of the
progression and pathology of the disease.