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Brief Communication Sleep deprivation and Pavlovian fear conditioning
 

Summary: Brief Communication
Sleep deprivation and Pavlovian fear conditioning
Denise J. Cai,1,3
Tristan Shuman,1
Elizabeth M. Harrison,1
Jennifer R. Sage,1
and Stephan
G. Anagnostaras1,2
1
Molecular Cognition Laboratory, Department of Psychology, University of California, San Diego, California 92093-0109, USA;
2
Program in Neurosciences, University of California, San Diego, California 92093-0109, USA
Sleep has been suggested to play a role in memory consolidation. Prior rodent studies have used sleep deprivation to
examine this relationship. First, we reexamined the effects of sleep deprivation on Pavlovian fear conditioning. We found
that the deprivation method itself (i.e., gentle handling) induced deficits independent of sleep. Second, we examined an
alternative method of sleep deprivation using amphetamine and found that this method failed to induce amnesia. These
data indicate that sleep deprivation is a problematic way to examine the role of sleep in memory consolidation, and an
alternative paradigm is proposed.
A growing body of evidence suggests that sleep plays a role in
memory consolidation, although the exact nature of this relation-

  

Source: Anagnostaras, Stephan - Neurosciences Program & Department of Psychology, University of California at San Diego

 

Collections: Biology and Medicine