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Summary: Molecular Cell
Short Article
Diverse Two-Dimensional Input Functions
Control Bacterial Sugar Genes
Shai Kaplan,1,2,3 Anat Bren,1,3,* Alon Zaslaver,1 Erez Dekel,1 and Uri Alon1
1Department of Molecular Cell Biology
2Department of Biological Chemistry
Weizmann Institute of Science, Rehovot 76100, Israel
3These authors contributed equally to this work.
*Correspondence: anat.bren@weizmann.ac.il
DOI 10.1016/j.molcel.2008.01.021
SUMMARY
Cellsrespondtosignalsbyregulatinggeneexpression.
The relation between the level of input signals and the
transcription rate of the gene is called the gene's input
function. Because most genes are regulated by more
than one signal, the input functions are usually multidi-
mensional. To understand cellular responses, it is es-
sential to know the shapes of these functions. Here,
we map the two-dimensional input functions of 19
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