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Genome-wide RNAi screens in Caenorhabditis elegans: impact on cancer Gino Poulin1
 

Summary: Genome-wide RNAi screens in Caenorhabditis elegans: impact on cancer
research
Gino Poulin1
, Ramkumar Nandakumar1
and Julie Ahringer*,1
1
The Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
Genes linked to human cancers often function in evolu-
tionary conserved pathways, and research in C. elegans
has been instrumental in dissecting some of the pathways
affected, such as apoptosis and Ras signalling. The advent
of RNA interference (RNAi) technology has allowed high-
throughput loss-of-function analyses of C. elegans gene
functions. Here we review some of the most recent
genome-wide RNAi screens that have been conducted
and discuss their impact on cancer research and possibi-
lities for future screens. We also show that genes causally
implicated in human cancers are significantly more likely
to have a C. elegans homologue than average, validating
the use of C. elegans as a cancer gene discovery platform.

  

Source: Ahringe, Julie - Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge

 

Collections: Biology and Medicine