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www.landesbioscience.com Cell Cycle 2581 Cell Cycle 9:13, 2581-2588; July 1, 2010; 2010 Landes Bioscience
 

Summary: www.landesbioscience.com Cell Cycle 2581
Cell Cycle 9:13, 2581-2588; July 1, 2010; 2010 Landes Bioscience
RepoRt RepoRt
*Correspondence to: Trisha N. Davis; Email: tdavis@u.washington.edu
Submitted: 03/23/10; Revised: 04/05/10; Accepted: 04/12/10
Previously published online: www.landesbioscience.com/journals/cc/article/12076
DOI: 10.4161/cc.9.13.12076
Introduction
During mitosis, chromosomes congress to the equator of the
mitotic spindle. Positioning of the chromosomes depends in part
on the highly conserved kinesin-8 family of molecular motors.1-5
The kinesin-8s are plus-end directed microtubule motors that
localize to the mitotic spindle.1,2,6-9
In Schizosaccharomyces pombe,
Drosophila and mammalian systems, the role of the kinesin-8
motor in chromosome congression has been established.3,10-12
The kinesin-8 in S. cerevisiae is Kip3. Kip3 has been shown to
regulate the plus-end dynamics of cytoplasmic microtubules in
order to position the nucleus at the bud neck prior to anaphase.6,13,14
Kip3 also localizes to microtubules of the mitotic spindle.8,14

  

Source: Asbury, Chip - Department of Physiology and Biophysics, University of Washington at Seattle

 

Collections: Biology and Medicine