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Defining the sequence-recognition profile of DNA-binding molecules
 

Summary: Defining the sequence-recognition profile
of DNA-binding molecules
Christopher L. Warren
, Natasha C. S. Kratochvil
, Karl E. Hauschild
, Shane Foister§
, Mary L. Brezinski
,
Peter B. Dervan§
, George N. Phillips, Jr.
, and Aseem Z. Ansari¶
Department of Biochemistry and Genome Center, University of Wisconsin, Madison, WI 53706; and §Division of Chemistry and Chemical Engineering,
California Institute of Technology, Pasadena, CA 91125
Contributed by Peter B. Dervan, November 11, 2005
Determining the sequence-recognition properties of DNA-binding
proteins and small molecules remains a major challenge. To ad-
dress this need, we have developed a high-throughput approach
that provides a comprehensive profile of the binding properties of
DNA-binding molecules. The approach is based on displaying every
permutation of a duplex DNA sequence (up to 10 positional

  

Source: Ansari, Aseem Z. - Department of Biochemistry, University of Wisconsin at Madison
Stoltz, Brian M. - Division of Chemistry and Chemical Engineering, California Institute of Technology

 

Collections: Biology and Medicine; Chemistry