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The International HapMap Project The International HapMap Consortium*
 

Summary: The International HapMap Project
The International HapMap Consortium*
*Lists of participants and affiliations appear at the end of the paper
...........................................................................................................................................................................................................................
The goal of the International HapMap Project is to determine the common patterns of DNA sequence variation in the human genome
and to make this information freely available in the public domain. An international consortium is developing a map of these
patterns across the genome by determining the genotypes of one million or more sequence variants, their frequencies and the
degree of association between them, in DNA samples from populations with ancestry from parts of Africa, Asia and Europe. The
HapMap will allow the discovery of sequence variants that affect common disease, will facilitate development of diagnostic tools,
and will enhance our ability to choose targets for therapeutic intervention.
C
ommon diseases such as cardiovascular disease, cancer,
obesity, diabetes, psychiatric illnesses and inflammatory
diseases are caused by combinations of multiple genetic
and environmental factors1
. Discovering these genetic
factors will provide fundamental new insights into the
pathogenesis, diagnosis and treatment of human disease. Searches
for causative variants in chromosome regions identified by linkage
analysis have been highly successful for many rare single-gene

  

Source: Abecasis, Goncalo - Department of Biostatistics, University of Michigan
Kruglyak, Leonid - Lewis-Sigler Institute for Integrative Genomics & Department of Ecology and Evolutionary Biology, Princeton University

 

Collections: Biology and Medicine; Mathematics