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nature neurOSCIenCe VOLUME 14 | NUMBER 6 | JUNE 2011 775 a r t I C l e S

Summary: nature neurOSCIenCe VOLUME 14 | NUMBER 6 | JUNE 2011 775
a r t I C l e S
In an uncertain environment, organisms often need to react quickly
to subtle changes in their surroundings. Integrating inputs from mul-
tiple sensory systems (for example, vision, audition and somatosensa-
tion) can increase perceptual sensitivity, enabling better detection or
discrimination of events in the environment13. A basic question in
multisensory integration is: how do single neurons combine their uni-
sensory inputs? Although neurophysiological studies have revealed
a set of empirical principles by which two sensory inputs interact
to modify neural responses4, the computations performed by neural
circuits that integrate multisensory inputs are not well understood.
A prominent feature of multisensory integration is the principle of
for weak multimodal stimuli and decreases with stimulus intensity47.
and temporally synchronous for robust multisensory enhancement to
occur, with large spatial or temporal offsets leading instead to response
suppression810. Although these empirical principles are well established,


Source: Angelaki, Dora - Department of Anatomy and Neurobiology, Washington University in St. Louis
DeAngelis, Gregory - Department of Brain and Cognitive Sciences, University of Rochester


Collections: Biology and Medicine