Summary: © 2002 Freund Publishing House, Ltd. 1
GENETICS OF DEAFNESS: RECENT ADVANCES
AND CLINICAL IMPLICATIONS
and Karen B. Avraham2
Department of Otolaryngology/Head and Neck Surgery,
Hadassah University Hospital, Jerusalem and
Department of Human Genetics and Molecular Medicine,
Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Genetic research into the causes of deafness has advanced
considerably in the last years. Progress has been made in both
discovering loci and cloning genes associated with syndromic and
non-syndromic hearing loss. To date, close to 75 loci have been
identified and 29 genes have been cloned for non-syndromic deafness.
The proteins these genes encode range from transcription factors to
molecular motors to ion channels. We review the recent discoveries
and discuss the impact of this research.