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Z .Brain Research 765 1997 331336 Short communication

Summary: Z .Brain Research 765 1997 331­336
Short communication
Local opiate withdrawal in locus coeruleus in vivo
G. Aston-Jones )
, H. Hirata, H. Akaoka 1
Department of Psychiatry, DiĠision of BehaĠioral Neurobiology, Allegheny-Hahnemann Medical School, Mail Stop 403, Broad and Vine, Philadelphia, PA
19102, USA
Accepted 20 May 1997
Z .Hyperactivity of noradrenergic locus coeruleus LC neurons following withdrawal from chronic opiates has been implicated in the
opiate withdrawal syndrome. Here, we report that local withdrawal induced in vivo by microinfusion of an opiate antagonist into the LC
of morphine-dependent rats marginally, but significantly, activated LC neurons above the level obtained with local naloxone microinfu-
Z .sion in naive rats. This local withdrawal response contributes a significant fraction ;19% of the total LC hyperactivity induced by
systemic naloxone. q 1997 Elsevier Science B.V.
Keywords: Opiate withdrawal; Locus coeruleus; Norepinephrine; Excitatory amino acid; Electrophysiology
Z .Noradrenergic locus coeruleus LC neurons in rats
chronically treated with morphine exhibit pronounced hy-
Z .peractivity in response to intravenous i.v. injection of
w xopiate antagonists such as naloxone 1,6 . This hyperactiv-
ity in LC neurons has been proposed to play an important


Source: Aston-Jones, Gary - Department of Neurosciences, Medical University of South Carolina


Collections: Biology and Medicine