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Neogenin, an Avian Cell Surface Protein Expressed during Terminal Neuronal Differentiation, Is Closely Related to the
 

Summary: Neogenin, an Avian Cell Surface Protein Expressed during
Terminal Neuronal Differentiation, Is Closely Related to the
Human Tumor Suppressor Molecule Deleted in Colorectal Cancer
Jost Vielmetter, Jon E Kayyem, Janet M. Roman, and William J. Dreyer
DivisionofBiology,156-29,CaliforniaInstituteofTechnology,Pasadena,California91125
Abstract. Using a monoclonal antibody, we have
identified and characterized a previously unknown cell
surface protein in chicken that we call neogenin and
have determined its primary sequence. The deduced
amino acid sequence and structure of neogenin charac-
terize it as a member of the immunoglobulin (Ig) su-
perfamily. Based on amino acid sequence similarities,
neogenin is closely related to the human tumor sup-
pressor molecule DCC (deleted in colorectal cancer).
Neogenin and DCC define a subgroup of Ig super-
family proteins structurally distinct from other Ig mol-
ecules such as N-CAM, Ng-CAM, and Bravo/Nr-CAM.
As revealed by antibody staining of tissue sections and
Western blots, neogenin expression correlates with the
onset of neuronal differentiation. Neogenin is also

  

Source: Adolphs, Ralph - Psychology and Neuroscience, California Institute of Technology

 

Collections: Biology and Medicine