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Errors in DNA Self-Assembly By Synthesized Tile Sets X. Ma, M. Hashempour, Y.B. Kim and F.Lombardi
 

Summary: Errors in DNA Self-Assembly By Synthesized Tile Sets
X. Ma, M. Hashempour, Y.B. Kim and F.Lombardi
Dept of Electrical and Computer Engineering
Northeastern University
Boston, MA 02115
{xma,masoud, ybk,lombardi}@ece.neu.edu
Abstract
This paper presents a study of errors that occur in DNA self-assembly using synthesized tile sets
for template manufacturing. It is shown that due to the reduced size, aggregates assembled by a
synthesized tile set are not error-free as those assembled by maximum-sized (referred to as a trivial
tile set) as well asnon-synthesized tile sets. Compared with non-synthesized tile sets, aggregates
assembled using synthesized tile sets also have a higher error rate at high tile concentration, but
they exhibit a lower rate at low tile concentration. In this paper, it is also shown that errors in
synthesized tile sets tend to appear in clusters. This is very different from non-synthesized tile
sets of non-maximum size in which growth errors are mostly random in nature. These findings
are discussed and evaluated for nano manufacturing (such as for template self-assembly of a QCA
circuit).
Index Terms: DNA Self-assembly, error analysis, nanoscale manufacturing, tile set, emerging
technologies.
1 Introduction

  

Source: Ayers, Joseph - Marine Science Center & Department of Biology, Northeastern University

 

Collections: Engineering