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Understanding the dynamics and function of cellular networks
 

Summary: Understanding the dynamics and function of
cellular networks
Cells are complex systems
ˇ functionally diverse elements
ˇ diverse interactions that form networks
ˇ signal transduction-, gene regulatory-, metabolic-
ˇ have a function that needs to be performed
ˇ sense and respond to the environment
ˇ maintain homeostasis
ˇ replicate
ˇ need certain dynamical features
ˇ sensitive to some changes, insensitive/adaptable to others
ˇ robust to unwanted perturbations
ˇ evolvable, shaped by evolution
ˇ Which network topological features can ensure reliable and robust
dynamics?
Signaling, gene regulation and protein
interactions are intertwined
Mapping of cellular interaction networks
Experimental advances allow the construction of genome-wide

  

Source: Albert, Réka - Departments of Biology & Physics, Pennsylvania State University

 

Collections: Biology and Medicine