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Function and Structural Organization of Mot1 Bound to a Natural Target Promoter*S
 

Summary: Function and Structural Organization of Mot1 Bound to a
Natural Target Promoter*S
Received for publication,May 15, 2008, and in revised form, July 1, 2008 Published, JBC Papers in Press,July 7, 2008, DOI 10.1074/jbc.M803749200
Rebekka O. Sprouse
, Inna Shcherbakova§
, Huiyong Cheng§
, Elizabeth Jamison§
, Michael Brenowitz§
,
and David T. Auble1
Fromthe
DepartmentofBiochemistryandMolecularGenetics,UniversityofVirginiaHealthSystem,Charlottesville,Virginia22908
and the §
Department of Biochemistry, The Albert Einstein College of Medicine, Bronx, New York 10461
Mot1 is an essential, conserved TATA-binding protein
(TBP)-associated factor in Saccharomyces cerevisiae and a
member of the Snf2/Swi2 ATPase family. Mot1 uses ATP
hydrolysis to displace TBP from DNA, an activity that can be
readily reconciled with its global role in gene repression. Less
well understood is how Mot1 directly activates gene expression.

  

Source: Auble, David - Department of Biochemistry and Molecular Genetics, University of Virginia

 

Collections: Biology and Medicine