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J Physiol 575.2 (2006) pp 583602 583 Efficacy and connectivity of intracolumnar pairs of layer
 

Summary: J Physiol 575.2 (2006) pp 583­602 583
Efficacy and connectivity of intracolumnar pairs of layer
2/3 pyramidal cells in the barrel cortex of juvenile rats
Dirk Feldmeyer1,2
, Joachim L¨ubke2,3
and Bert Sakmann1
1
Abteilung Zellphysiologie, Max-Planck-Institut f¨ur medizinische Forschung, Jahnstr. 29, D-69120 Heidelberg, Germany
2
Institut f¨ur Neurowissenschaften und Biophysik-Medizin, Forschungszentrum J¨ulich, D-52425 J¨ulich, Germany
3
Institut f¨ur Anatomie und Zellbiologie der Albert-Ludwigs-Universit¨at Freiburg, Albertstraße 17, D-79104 Freiburg i.Br, Germany
Synaptically coupled layer 2/3 (L2/3) pyramidal neurones located above the same layer 4 barrel
(`barrel-related') were investigated using dual whole-cell voltage recordings in acute slices of rat
somatosensory cortex. Recordings were followed by reconstructions of biocytin-filled neurones.
The onset latency of unitary EPSPs was 1.1 ± 0.4 ms, the 20­80% rise time was 0.7 ± 0.2 ms,
the average amplitude was 1.0 ± 0.7 mV and the decay time constant was 15.7 ± 4.5 ms. The
coefficient of variation (C.V.) of unitary EPSP amplitudes decreased with increasing EPSP peak
and was 0.33 ± 0.18. Bursts of APs in the presynaptic pyramidal cell resulted in EPSPs that,
over a wide range of frequencies (5­100 Hz), displayed amplitude depression. Anatomically the

  

Source: Andrzejak, Ralph Gregor - Departament de Tecnologia, Universitat Pompeu Fabra

 

Collections: Computer Technologies and Information Sciences