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978-1-4244-2599-0/08/$25.00 2009 IEEE -page number-ISOCC 2009 Error Tolerant DNA Self-Assembly by Link-

Summary: 978-1-4244-2599-0/08/$25.00 2009 IEEE -page number- ISOCC 2009
Error Tolerant DNA Self-Assembly by Link-
Young Bok Kim, Yong-Bin Kim, and F. Lombardi
Dept of Electrical and Computer Engineering
Northeastern University
Boston, USA
Abstract--This paper proposes and evaluates link fracturing as
an approach for error tolerance in self-assembly by utilizing a
DNA chain as a link between two blocks of molecules. Through
the use of restriction enzymes, link fracturing breaks the
connecting DNA chain between two blocks if an incorrect
assembly has occurred due to the erroneous growth of tiles. Two
error tolerant techniques are proposed by fracturing of the DNA
chain links, namely 1-link and 2-link. Using the tool Xgrow,
simulations under the Kinetic Tile Assembly Model (KTAM) are
performed. Results show that 2-link fracturing achieves an
improvement in error rate as compared to a normal assembly;
moreover this is accomplished with little overhead in assembly


Source: Ayers, Joseph - Marine Science Center & Department of Biology, Northeastern University


Collections: Engineering