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GLUTAMATE-ASSOCIATED PLASTICITY IN THE VENTRAL TEGMENTAL AREA IS NECESSARY FOR CONDITIONING
 

Summary: GLUTAMATE-ASSOCIATED PLASTICITY IN THE VENTRAL
TEGMENTAL AREA IS NECESSARY FOR CONDITIONING
ENVIRONMENTAL STIMULI WITH MORPHINE
G. C. HARRIS, M. WIMMER, R. BYRNE AND
G. ASTON-JONES*
Department of Psychiatry, University of Pennsylvania, 705 Stellar
Chance/6100, 422 Curie Boulevard, Philadelphia, PA 19104-6100,
USA
Abstract--We sought to determine if plasticity in the ventral
tegmental area (VTA) of the midbrain is involved in learning
to associate morphine exposure with a specific environment.
For this, we tested whether activation of glutamate receptors
and protein kinase A is needed for the acquisition and ex-
pression of a morphine-conditioned place preference (CPP).
Rats received bilateral microinjections of either the NMDA
antagonist AP5 (0.48 nmol/0.3 l), the AMPA antagonist
CNQX (0.21 nmol/0.3 l), or vehicle into the VTA prior to each
of three morphine-conditioning sessions. Both the AMPA and
NMDA receptor antagonists blocked the development of mor-
phine CPP when given into the VTA but not when given

  

Source: Aston-Jones, Gary - Department of Neurosciences, Medical University of South Carolina

 

Collections: Biology and Medicine