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Role for -catenin and HOX transcription factors in Caenorhabditis elegans and mammalian host
 

Summary: Role for -catenin and HOX transcription factors
in Caenorhabditis elegans and mammalian host
epithelial-pathogen interactions
Javier E. Irazoquia,b,c
, Aylwin Ngc
, Ramnik J. Xavierc
, and Frederick M. Ausubela,b,c,1
aDepartment of Genetics, Harvard Medical School, and bDepartment of Molecular Biology and cCenter for Computational and Integrative Biology,
Massachusetts General Hospital, Boston, MA 02114
Contributed by Frederick M. Ausubel, September 24, 2008 (sent for review August 8, 2008)
We used the model nematode Caenorhabditis elegans infected
with the human pathogen Staphylococcus aureus to identify com-
ponents of epithelial immunity. Transcriptional profiling and re-
verse genetic analysis revealed that mutation of the C. elegans
-catenin homolog bar-1 or the downstream homeobox gene egl-5
results in a defective response and hypersensitivity to S. aureus
infection. Epistasis analysis showed that bar-1 and egl-5 function
in parallel to previously described C. elegans immune-response
pathways. Overexpression of human homologs of egl-5 modulated
NF- B-dependent TLR2 signaling in epithelial cells. These data

  

Source: Ausubel, Frederick M. - Department of Genetics, Harvard University

 

Collections: Biology and Medicine