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JCB: Article The Rockefeller University Press $30.00

Summary: JCB: Article
The Rockefeller University Press $30.00
J. Cell Biol. Vol. 188 No. 2 287297
www.jcb.org/cgi/doi/10.1083/jcb.200906139 JCB 287
Correspondence to Maxime F. Fournier: maxime.fournier@epfl.ch
During cell migration, forces developed in the actin micro-
filament system are transmitted to the substrate to drive cell
motion. The major force-generating reactions in the cytoskeleton
are believed to be the assembly of actin filaments and their inter-
action with the motor protein myosin II (Mitchison and Cramer,
1996; Mogilner and Oster, 2003; Ridley et al., 2003). Actin as-
sembly is thought to drive protrusion at the leading edge of the
cell (Pantaloni et al., 2001; Mogilner and Oster, 2003; Pollard
and Borisy, 2003). In contrast, the role of myosin II is contro-
versial. By analogy to skeletal muscle, it was argued that inter-
action between actin and myosin filaments generates contractile
forces that pull the cell body forward and promote retraction at
the back of the cell (Maciver, 1996; Verkhovsky et al., 1999).
However, multiple studies demonstrated that the motor activity


Source: Ambrosi, Davide - Dipartimento di Matematica, Politecnico di Torino


Collections: Mathematics