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Summary: attention: Op18/stathmin; and the
small GTPase Ran. Phosphostate
gradients in Op18/stathmin, which
destabilizes microtubules at least
partly by tubulin sequestration in a
phosphorylation-dependent
manner [1113], have been directly
visualized in mitotic and interphase
cells using phosphostate-specific
fluorescence resonance energy
transfer (FRET) probes [14]. The
FRET analysis of Niethammer et al.
[14] indicates that a region favoring
microtubule assembly exists
between the poles in mitotic cells.
Phosphostate gradients in Ran,
which indirectly controls
microtubule assembly in mitosis
via TPX2 in a GTP/GDP-state
dependent manner [15,16], have
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