Summary: Failing Energetics in Failing Hearts
Petras P. Dzeja, PhD, Margaret M. Redfield, MD, FACC, John C. Burnett, MD,
and Andre Terzic, MD, PhD
Address
Division of Cardiovascular Diseases, Departments of Medicine,
Molecular Pharmacology and Experimental Therapeutics, and
Physiology, Mayo Clinic and Foundation, 200 First Street SW,
Guggenheim-7, Rochester, MN 55905, USA.
E-mail: terzic.andre@mayo.edu.
Current Cardiology Reports 2000, 2:212­217
Current Science Inc. ISSN 1523­3782
Copyright © 2000 by Current Science Inc.
Introduction
Maintenance of optimal cellular bioenergetics is an essen-
tial requirement for myocardial function, including normal
contraction and relaxation, as well as preservation of ion
homeostasis, signal transduction, and gene expression [1­
4]. Regardless of its diverse etiopathogenesis, heart failure is
characterized by progressive loss of a number of energy-
dependent cellular functions [5,6,7·]. In this regard,

Source: Akabas, Myles - Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University

Collections: Biology and Medicine