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ORIGINAL PAPER Abstract In isolated pea (Pisum sativum L.) mitochon-
 

Summary: ORIGINAL PAPER
Abstract In isolated pea (Pisum sativum L.) mitochon-
dria incorporation of 35S-methionine into newly synthe-
sised proteins was influenced by the presence of site-spe-
cific inhibitors of the respiratory electron-transport chain.
These effects were not produced by changes in the rate of
respiratory electron transport itself nor by changes in ATP
concentration. Protein synthesis was inhibited by inhibi-
tors of ubiquinone reduction but not by inhibitors of ubi-
quinol oxidation. By the use of additional inhibitors at spe-
cific sites of the respiratory chain, different oxidation-re-
duction states were obtained for the different complexes in
the electron-transport chain. It was found that electron
transport through succinate:ubiquinone oxidoreductase
(respiratory complex II) was specifically required for pro-
tein synthesis, even when all the other conditions for pro-
tein synthesis were satisfied. We suggest that a subunit of
complex II, or a component closely associated with com-
plex II, is involved in a regulatory system that couples elec-
tron transport to protein synthesis.

  

Source: Allen, John F. - School of Biological and Chemical Sciences, Queen Mary, University of London

 

Collections: Renewable Energy; Biology and Medicine