Summary: Helix-stabilized Fv (hsFv) Antibody Fragments:
Substituting the Constant Domains of a Fab Fragment
for a Heterodimeric Coiled-coil Domain
Katja M. Arndt1,2
, Kristian M. MuÈller1,2
and Andreas PluÈckthun1
*
1
Biochemisches Institut
UniversitaÈt ZuÈrich
Winterthurerstr. 190
8057 ZuÈrich, Switzerland
2
Department of Molecular and
Cell Biology, University of
California, 229 Stanley Hall
Berkeley, CA 94720-3206, USA
Antibody Fv fragments would in principle be useful for a variety of bio-
technological applications because of their small size and the possibility
to produce them in relatively large amounts in recombinant form; how-

Source: Arndt, Katja - Institut für Biologie III, Albert-Ludwigs-Universität Freiburg
Müller, Kristian - Institut für Biologie III, Albert-Ludwigs-Universität Freiburg

Collections: Biology and Medicine; Biotechnology