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Summary: DETECTING MAXIMAL DIRECTIONAL CHANGES IN SPATIAL FMRI RESPONSE USING
CANONICAL CORRELATION ANALYSIS
Bernard Ng1
, Rafeef Abugharbieh1
, Martin J. McKeown2
1
Biomedical Signal and Image Computing Lab, Department of Electrical Engineering
2
Department of Medicine (Neurology), Pacific Parkinson's Research Center,
The University of British Columbia, Vancouver, BC, Canada, bernardn@ece.ubc.ca
ABSTRACT
Traditional fMRI analysis has focused on modeling temporal
changes in BOLD signals on a voxel-by-voxel basis to infer
brain activation. To incorporate spatial information, we have
previously proposed to model the spatial changes in the
distribution of BOLD signals within regions of interest.
Specifically, we examined changes in the spread of BOLD
signals and the distribution of signals along the three
coordinate dimensions of the MR scanner to detect
activation. However, the scanner-based coordinate directions
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