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A proposal for tsetse fly (Glossina) genome projects Submitted April 30, 2010

Summary: 1
A proposal for tsetse fly (Glossina) genome projects
Submitted April 30, 2010
by Serap Aksoy on behalf of International Glossina Genomics Community
Executive Summary
The Glossina (tsetse flies) are vectors of African trypanosomes, which are of medical and economic
importance. 1.35 million DALYs are lost due to Human African Trypanosomiasis (HAT) and mortality
related to HAT is ranked ninth out of 25 among the human infectious and parasitic diseases in Africa.
Animal African Trypanosomiasis (AAT) causes approximately 3 million cattle deaths per year and
farmers administer about 35 million doses of trypanocidal drugs at a cost of US$ 1-1.2 billion, resulting
in total agricultural losses estimated at US$ 4.75 billion per year. Despite considerable research into
trypanosomes, the toolbox for disease control is limited with neither vaccines nor effective and
affordable drugs available in the near future. The African Union has made removal of trypanosomiasis
via tsetse control a key priority for the continent. New and/or improved control tools will be developed
through the expanded genomic resources proposed here.
This document proposes sequencing of 5 Glossina genomes (average size 400 Mb) and two related
Dipterans, a non-vector obligate blood feeder (stable fly, Stomoxys calcitrans) and a non-blood
feeding mechanical vector of numerous human pathogens (the house fly, Musca domestica). The data
will complement and facilitate comparative analysis with the nearly complete Glossina morsitans
morsitans genome and the available multiple Drosophila genomes. We propose deep sampling of two


Source: Aksoy, Serap - School of Public Health, Yale University


Collections: Biology and Medicine