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BioMed Central Page 1 of 13

Summary: BioMed Central
Page 1 of 13
(page number not for citation purposes)
BMC Evolutionary Biology
Open AccessResearch article
Phylogenomic analysis of natural selection pressure in Streptococcus
Maria Anisimova*1, Joseph Bielawski2,3, Katherine Dunn2 and Ziheng Yang1
Address: 1Department of Biology, University College London, London, UK, 2Department of Biology, Dalhousie University, Halifax, Nova Scotia,
Canada and 3Department of Mathematics and Statistics, Dalhousie University, Halifax, Nova Scotia, Canada
Email: Maria Anisimova* - manisimova@hotmail.com; Joseph Bielawski - j.bielawski@dal.ca; Katherine Dunn - kathy.dunn@dal.ca;
Ziheng Yang - z.yang@ucl.ac.uk
* Corresponding author
Background: In comparative analyses of bacterial pathogens, it has been common practice to
discriminate between two types of genes: (i) those shared by pathogens and their non-pathogenic
relatives (core genes), and (ii) those found exclusively in pathogens (pathogen-specific accessory
genes). Rather than attempting to a priori delineate genes into sets more or less relevant to
pathogenicity, we took a broad approach to the analysis of Streptococcus species by investigating the
strength of natural selection in all clusters of homologous genes. The genus Streptococcus is


Source: Anisimova, Maria - Institute of Scientific Computing, Eidgenössische Technische Hochschule Zürich (ETHZ)
Yang, Ziheng - Department of Genetics, Evolution and Environment, University College London


Collections: Biology and Medicine; Environmental Sciences and Ecology