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Summary: Neuron, Vol. 39, 423438, July 31, 2003, Copyright 2003 by Cell Press
Local Tissue Interactions across the Dorsal
Midline of the Forebrain Establish CNS Laterality
to the parapineal precursors. Ablation of cells in the
left ventral epithalamus can reverse laterality in wild-
type embryos and impose the direction of CNS asym-
Miguel L. Concha,1,2,8,
* Claire Russell,1,8
Jennifer C. Regan,1,9
Marcel Tawk,1,9
Samuel Sidi,3
Darren T. Gilmour,3
Marika Kapsimali,1
Lauro Sumoy,4
metry in embryos in which laterality is usually random-
ized. Unilateral modulation of Nodal activity by Lefty1Kim Goldstone,5
Enrique Amaya,5
David Kimelman,6
Teresa Nicolson,3
can also impose the direction of CNS laterality in em-
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