Home

About

Advanced Search

Browse by Discipline

Scientific Societies

E-print Alerts

Add E-prints

E-print Network
FAQHELPSITE MAPCONTACT US


  Advanced Search  

 
A system-level approach for deciphering the transcriptional response to prion infection
 

Summary: A system-level approach for deciphering the
transcriptional response to prion infection
Mattia Zampieri 1,2, Giuseppe Legname 2 , Daniel Segr`e 3,4 and Claudio
Altafini 2,
1
Institute of Molecular Systems Biology, ETH, Wolfgang-Pauli-Str. 16, 8093 Zurich, Switzerland
2
SISSA, Scuola Internazionale Superiore di Studi Avanzati, via Bonomea 265, 34136 Trieste, Italy
3
Bioinformatics Program, Boston University, 24 Cummington St., Boston, MA 02215, USA
4
Department of Biology and Department of Biomedical Engineering, Boston University, 44
Cummington St., Boston, MA 02215, USA
ABSTRACT
Motivation: Deciphering the response of a complex biological system
to an insulting event, at the gene expression level, requires adopting
theoretical models that are more sophisticated than a one-to-one
comparison (i.e. t-test). Here, we investigate the ability of a novel
reverse engineering approach ("System Response Inference") to
unveil non-obvious transcriptional signatures of the system response

  

Source: Altafini, Claudio - Functional Analysis Sector, Scuola Internazionale Superiore di Studi Avanzati (SISSA)

 

Collections: Engineering; Mathematics