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BioMed Central Page 1 of 8
 

Summary: BioMed Central
Page 1 of 8
(page number not for citation purposes)
BMC Neurology
Open AccessResearch article
Shape (but not volume) changes in the thalami in Parkinson disease
Martin J McKeown*1,2,3,4, Ashish Uthama4, Rafeef Abugharbieh2,4,
Samantha Palmer1, Mechelle Lewis5 and Xuemei Huang5
Address: 1Pacific Parkinson's Research Center, University of British Columbia, Vancouver, Canada, 2Brain Research Centre, University of British
Columbia, Vancouver, Canada, 3Department of Medicine (Neurology), University of British Columbia, Vancouver, Canada, 4Biomedical Signal
and Image Computing Lab, Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, Canada and
5Department of Neurology, University of North Carolina, Chapel Hill, NC, USA
Email: Martin J McKeown* - mmckeown@interchange.ubc.ca; Ashish Uthama - ashishu@ece.ubc.ca; Rafeef Abugharbieh - rafeef@ece.ubc.ca;
Samantha Palmer - sjpalmer@interchange.ubc.ca; Mechelle Lewis - lewism@neurology.unc.edu; Xuemei Huang - xuemei@med.unc.edu
* Corresponding author Equal contributors
Abstract
Background: Recent pathological studies have suggested that thalamic degeneration may
represent a site of non-dopaminergic degeneration in Parkinson's Disease (PD). Our objective was
to determine if changes in the thalami could be non-invasively detected in structural MRI images
obtained from subjects with Parkinson disease (PD), compared to age-matched controls.

  

Source: Abugharbieh, Rafeef - Department of Electrical and Computer Engineering, University of British Columbia

 

Collections: Biology and Medicine; Computer Technologies and Information Sciences