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BioMed Central Page 1 of 20

Summary: BioMed Central
Page 1 of 20
(page number not for citation purposes)
BMC Biology
Open AccessResearch article
Evolution favors protein mutational robustness in sufficiently large
Jesse D Bloom*1, Zhongyi Lu1, David Chen1, Alpan Raval2,
Ophelia S Venturelli1 and Frances H Arnold*1
Address: 1Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA and 2Keck
Graduate Institute of Applied Life Sciences and School of Mathematical Sciences, Claremont Graduate University, Claremont, CA 91711, USA
Email: Jesse D Bloom* - jesse.bloom@gmail.com; Zhongyi Lu - lu07@caltech.edu; David Chen - davidc@caltech.edu;
Alpan Raval - alpan_raval@kgi.edu; Ophelia S Venturelli - opheliav@stanford.edu; Frances H Arnold* - frances@cheme.caltech.edu
* Corresponding authors
Background: An important question is whether evolution favors properties such as mutational
robustness or evolvability that do not directly benefit any individual but can influence the course of
future evolution. Functionally similar proteins can differ substantially in their robustness to
mutations and capacity to evolve new functions, but it has remained unclear whether any of these
differences might be due to evolutionary selection for these properties.


Source: Arnold, Frances H. - Division of Chemistry and Chemical Engineering, California Institute of Technology


Collections: Chemistry; Biology and Medicine