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Biological Investigation Using Scanning Probe Recognition Microscopy

Summary: Biological Investigation Using Scanning Probe
Recognition Microscopy
Qian Chen, Virginia Ayres, Lalita Udpa
Dept. of Electrical and Computer Engineering
Michigan State University
East Lansing, MI 48824
Abstract--Direct investigation of, and interaction with, biological
objects at the macromolecular level will provide insight into
multiple physical regulatory processes. Scanning probe
microscopy (SPM) techniques have the potential to provide a
direct interaction with living specimens at the macromolecular
scale. In the present research we will discuss the site-specific
recognition techniques that are appropriate for biological objects
of different shapes in the SPM images. Moment-based shape
features which are scale and translation invariant are
successfully used to distinguish tubular objects from globular
objects. Among the globular objects, white blood cells can be
clearly classified from red blood cells by applying two-
dimensional continuous wavelet transform (CWT), which can
represent information of objects in multiple scales. The scan plan


Source: Ayres, Virginia - Department of Electrical and Computer Engineering, Michigan State University


Collections: Materials Science; Biology and Medicine