Summary: The EMBO Journal Vol.17 No.21 pp.6337­6347, 1998
Repression by the 3 UTR of fem-3, a
sex-determining gene, relies on a ubiquitous
mog-dependent control in Caenorhabditis elegans
Maria Gallegos1, Julie Ahringer2,
Sarah Crittenden3 and Judith Kimble1,3,4,5
1Program of Cellular and Molecular Biology, 3Howard Hughes
Medical Institute, 4Departments of Biochemistry and Medical Genetics
and Laboratory of Cell and Molecular Biology, University of
Wisconsin-Madison, 433 Babcock Drive, Room 341E, Madison,
WI 53706, USA and 2Wellcome CRC Institute, Tennis Court Road,
Cambridge CB2 1QR, UK
5Corresponding author
e-mail: jekimble@facstaff.wisc.edu
The fem-3 sex-determining gene is repressed post-
transcriptionally via a regulatory element in its 3
untranslated region (UTR) to achieve the switch from
spermatogenesis to oogenesis in the Caenorhabditis
elegans hermaphrodite germ line. In this paper, we
investigate the fem-3 3 UTR control in somatic tissues

Source: Ahringe, Julie - Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
Kimble, Judith - Department of Biochemistry, University of Wisconsin at Madison

Collections: Biology and Medicine