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Research article TheJournalofClinicalInvestigation http://www.jci.org Volume117 Number8 August2007 2095
 

Summary: Research article
TheJournalofClinicalInvestigation http://www.jci.org Volume117 Number8 August2007 2095
Proteolytic processing of dynamin by
cytoplasmic cathepsin L is a mechanism
for proteinuric kidney disease
Sanja Sever,1 Mehmet M. Altintas,1 Sharif R. Nankoe,1 Clemens C. Möller,1 David Ko,1
Changli Wei,1 Joel Henderson,2 Elizabetta C. del Re,1 Lianne Hsing,3 Ann Erickson,4
Clemens D. Cohen,5 Matthias Kretzler,6 Dontscho Kerjaschki,7 Alexander Rudensky,3,8
Boris Nikolic,1 and Jochen Reiser1
1Department of Medicine, Nephrology Division and Program in Glomerular Disease, Massachusetts General Hospital (MGH) and Harvard Medical School,
Boston, Massachusetts, USA. 2Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
3Department of Immunology, University of Washington, Seattle, Washington, USA. 4Department of Biochemistry and Biophysics,
The University of North Carolina, Chapel Hill, North Carolina, USA. 5Medizinische Poliklinik, University of Munich, Munich, Germany.
6Department of Internal Medicine, Division of Nephrology, University of Michigan Medical School, Ann Arbor, Michigan, USA. 7Clinical Institute of Pathology,
Vienna Medical University, Vienna, Austria. 8Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, Washington, USA.
Kidneypodocytesandtheirfootprocessesmaintaintheultrafiltrationbarrierandpreventurinaryproteinloss
(proteinuria).HereweshowthattheGTPasedynaminisessentialforpodocytefunction.Duringproteinuric
kidneydisease,inductionofcytoplasmiccathepsinLleadstocleavageofdynaminatanevolutionarycon-
servedsite,resultinginreorganizationofthepodocyteactincytoskeletonandproteinuria.Dynaminmutants
thatlackthecathepsinLsite,orrenderthecathepsinLsiteinaccessiblethroughdynaminself-assembly,are

  

Source: Akabas, Myles - Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University

 

Collections: Biology and Medicine