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Summary: An Algorithm for Autonomous Isolation
of Neurons in Extracellular Recordings
Edward A. Branchaud and Joel W. Burdick
Mechanical Engineering
California Institute of Technology
Pasadena, CA 91125
eddie@caltech.edu
Richard A. Andersen
Dept. of Biology
California Institute of Technology
Pasadena, CA 91125
Abstract-- This paper describes novel multi-electrode sys-
tems that can autonomously position recording electrodes
inside cortical tissue so as to isolate and then maintain
optimal extracellular signal recording quality without human
intervention. Autonomous microdrives can be used to improve
the quality and efficiency of acute recordings that are needed
for basic research in neurophysiology. They also offer the
potential to increase the longevity and quality of chronic
recordings and will serve as the front end of neuroprosthetic
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