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Neuron, Vol. 17, 245254, August, 1996, Copyright 1996 by Cell Press Inhibition of FGF Receptor Activity
 

Summary: Neuron, Vol. 17, 245254, August, 1996, Copyright 1996 by Cell Press
Inhibition of FGF Receptor Activity
in Retinal Ganglion Cell Axons
Causes Errors in Target Recognition
Sarah McFarlane,* Elsa Cornel,* Enrique Amaya, be easily amenable to experimental manipulation, thus
providing a very attractive system for studying the mo-and Christine E. Holt*
*Department of Biology lecular mechanisms of axon guidance in the developing
vertebrate nervous system (Holt and Harris, 1993). InUniversity of California, San Diego
La Jolla, California 92093-0366 this system, TK activity is postulated to play a role in
axon extension (Worley and Holt, 1996), arborizationDepartment of Molecular and Cell Biology
University of California, Berkeley (Cohen-Cory and Fraser, 1995), and the formation of
appropriate topographic connections within the opticBerkeley, California 94720
tectum (Drescher et al., 1995; Cheng et al., 1995). Our
recent findings in Xenopus laevis have implicated the
fibroblast growth factor RTK (FGFR) in axon growth andSummary
guidance in the developing visual system (McFarlane et
al., 1995). We showed that FGF-2 (basic FGF) is presentNative fibroblast growth factor receptor (FGFR) func-
in the developing optic tract, where it may act on FGFRstion was inhibited in developing Xenopus retinal gan-
in retinal ganglion cell (RGC) growth cones to promoteglion cells (RGCs) by in vivo transfection of a dominant
axon growth along the optic pathway. A novel role fornegative FGFR. Axons expressing the dominant nega-

  

Source: Amaya, Enrique - Healing Foundation Centre & Developmental Biology, Faculty of Life Sciences, University of Manchester

 

Collections: Biology and Medicine