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1998 Oxford University Press 13931398Human Molecular Genetics, 1998, Vol. 7, No. 9 Genome-wide search for asthma susceptibility loci in
 

Summary:  1998 Oxford University Press 13931398Human Molecular Genetics, 1998, Vol. 7, No. 9
Genome-wide search for asthma susceptibility loci in
a founder population
Carole Ober*, Nancy J. Cox1, Mark Abney, Anna Di Rienzo, Eric S. Lander2,
Benjarat Changyaleket, Heidi Gidley, Bradley Kurtz, June Lee, Marcus Nance,
Anna Pettersson2, Joyce Prescott, Anthony Richardson, Evelyn Schlenker3,
Eleanor Summerhill1, Stephanie Willadsen and Rodney Parry3 and the Collaborative
Study on the Genetics of Asthma
Department of Human Genetics and 1Department of Medicine, University of Chicago, 924 East 57th Street,
Chicago, IL 60637, USA, 2Whitehead Institute/MIT Center for Genome Research, One Kendall Square, Bldg 300,
Cambridge, MA 02139-1561, USA and 3Department of Medicine, University of South Dakota School of Medicine,
1400 West 22nd Street, Sioux Falls, SD 57105-157, USA
Received April 6, 1998; Revised and Accepted June 5, 1998
Founder populations offer many advantages for
mapping genetic traits, particularly complex traits that
are likely to be genetically heterogeneous. To identify
genes that influence asthma and asthma-associated
phenotypes, we conducted a genome-wide screen in
the Hutterites, a religious isolate of European ancestry.
A primary sample of 361 individuals and a replication

  

Source: Abney, Mark - Department of Human Genetics, University of Chicago
Cox, Nancy J. - Section of Genetic Medicine, Department of Medicine, University of Chicago

 

Collections: Biology and Medicine; Computer Technologies and Information Sciences