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nature genetics advance online publication 1 Network motifs in the transcriptional regulation
 

Summary: letter
nature genetics advance online publication 1
Network motifs in the transcriptional regulation
network of Escherichia coli
Shai S. Shen-Orr1, Ron Milo2, Shmoolik Mangan1 & Uri Alon1,2
1Department of Molecular Cell Biology, 2Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot 76100, Israel. Correspondence
should be addressed to U.A. (e-mail: urialon@wisemail.weizmann.ac.il).
Little is known about the design principles110 of transcrip-
tional regulation networks that control gene expression in
cells. Recent advances in data collection and analysis2,11,12,
however, are generating unprecedented amounts of informa-
tion about gene regulation networks. To understand these
complex wiring diagrams110,13, we sought to break down such
networks into basic building blocks2. We generalize the notion
of motifs, widely used for sequence analysis, to the level of
networks. We define `network motifs' as patterns of intercon-
nections that recur in many different parts of a network at fre-
quencies much higher than those found in randomized
networks. We applied new algorithms for systematically
detecting network motifs to one of the best-characterized reg-

  

Source: Alon, Uri - Departments of Molecular Cell Biology & Physics of Complex Systems, Weizmann Institute of Science

 

Collections: Biology and Medicine